A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model

Abstract Abdominal aortic aneurysm (AAA) is a deadly, permanent ballooning of the aortic artery. Pharmacological and genetic studies have pointed to multiple proteins, including microsomal prostaglandin E2 synthase-1 (mPGES-1), as potentially promising targets. However, it remains unknown whether ad...

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Principais autores:	Lauren M. Weaver, Madeline J. Stewart, Kai Ding, Charles D. Loftin, Fang Zheng, Chang-Guo Zhan
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-03-01
Serija:	Scientific Reports
Teme:	Aneurysm Abdominal aortic aneurysm Prostaglandin E2 mPGES-1 inhibitor Anti-inflammation
Online dostop:	https://doi.org/10.1038/s41598-024-57437-9
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