Topiramate versus naltrexone for alcohol use disorder: study protocol for a genotype-stratified, double-blind randomised controlled trial (TOP study)

Abstract Background Current treatments for alcohol use disorders have limited efficacy and there is a high degree of variability in treatment response. In a randomised, placebo-controlled clinical trial, there was a large effect size for topiramate in people homozygous for the GRIK1 rs2832407*C alle...

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Autors principals:	Kirsten C. Morley, Henry R. Kranzler, Natasha Luquin, Andrew Baillie, Marian Shanahan, Ronald Trent, Maree Teesson, Paul S. Haber
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-08-01
Col·lecció:	Trials
Matèries:	Topiramate Alcohol use disorder Pharmacogenetics Naltrexone Alcohol dependence GRIK1
Accés en línia:	http://link.springer.com/article/10.1186/s13063-018-2824-z
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