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A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly up-regulated in breast, prostate, and colon cancer. Currently, growing interest is focusing on the identification and development of new inhibitors ab...

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Principais autores: José A. Souto, Federica Sarno, Angela Nebbioso, Chiara Papulino, Rosana Álvarez, Jessica Lombino, Ugo Perricone, Alessandro Padova, Lucia Altucci, Ángel R. de Lera
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-05-01
Serier:Frontiers in Chemistry
Fag:
cancer
epigenetics
Jumonji C
histone lysine demethylases
KDM4A enzymes
purpurogallin
Online adgang:https://www.frontiersin.org/article/10.3389/fchem.2020.00312/full
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