High concentrations of phenylalanine stimulate peroxisome proliferator-activated receptor γ: Implications for the pathophysiology of phenylketonuria

If left untreated, the common inherited metabolic disorder phenylketonuria (PKU) presents with mental retardation and reduced brain weight. The underlying molecular reasons for these deficits are unknown so far. Using human neuroblastoma cells as a model for normal human neuroblasts, elevated phenyl...

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Bibliografiske detaljer

Principais autores:	Udo Schumacher, Zoltan Lukacs, Christian Kaltschmidt, Christian Freudlsperger, Dorothea Schulz, Kai Kompisch, Reinhard Müller, Tanja Rudolph, René Santer, Dietrich E. Lorke, Kurt Ullrich
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2008-12-01
Serier:	Neurobiology of Disease
Fag:	Phenylketonuria Peroxisome proliferator-activated receptor gamma Pathophysiology Neuroblastoma cells
Online adgang:	http://www.sciencedirect.com/science/article/pii/S096999610800185X
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