Engineering a novel endopeptidase based on SARS 3CLpro
A 3C-like protease (3CLpro) from the severe acute respiratory syndrome–coronavirus (SARS-CoV) is required for viral replication, cleaving the replicase polyproteins at 11 sites with the conserved Gln↓(Ser, Ala, Gly) sequences. In this study, we developed a mutant 3CLpro (T25G) with an expanded S1′ s...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Taylor & Francis Group
2009-12-01
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| Серія: | BioTechniques |
| Предмети: | |
| Онлайн доступ: | https://www.future-science.com/doi/10.2144/000113303 |
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