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MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

<p>Abstract</p> <p>Background</p> <p>Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry process. The CD4 binding site (CD4bs) of gp120, and especially a recessed cavity occupied by the CD4 Ph...

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Hlavní autoři: Grupping Katrijn, Selhorst Philippe, Michiels Johan, Vereecken Katleen, Heyndrickx Leo, Kessler Pascal, Vanham Guido, Martin Loïc, Ariën Kevin K
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2012-05-01
Edice:Retrovirology
Témata:
HIV-1
Resistance
Entry inhibitors
CD4 binding site
Entry efficiency
On-line přístup:http://www.retrovirology.com/content/9/1/36
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