Sensitive inference of alignment-safe intervals from biodiverse protein sequence clusters using EMERALD

Abstract Sequence alignments are the foundations of life science research, but most innovation so far focuses on optimal alignments, while information derived from suboptimal solutions is ignored. We argue that one optimal alignment per pairwise sequence comparison is a reasonable approximation whe...

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Detalhes bibliográficos

Principais autores:	Andreas Grigorjew, Artur Gynter, Fernando H. C. Dias, Benjamin Buchfink, Hajk-Georg Drost, Alexandru I. Tomescu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-07-01
coleção:	Genome Biology
Assuntos:	Sequence alignment Dynamic programming Needleman-Wunsch algorithm Protein folding Suboptimal alignments
Acesso em linha:	https://doi.org/10.1186/s13059-023-03008-6
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