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Novel Method for Predicting Lp(a) From Genomic Testing Identifies ASCVD Risk Across a Diverse Cohort

Summary: Lipoprotein(a) (Lp[a]) is a genetic and often unmeasured contributor to atherosclerotic cardiovascular disease (ASCVD) risk. In this study, Lp(a) was estimated from exome data by quantifying Kringle IV subtype 2 repeats alongside a single-nucleotide variant–based genetic risk score. This me...

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Principais autores: Natalie Telis, PhD, Hang Dai, PhD, Ashley Waring, MD, David Kann, MD, Dana Wyman, PhD, Simon White, MSc, Basil Khuder, MS, Francisco Tanudjaja, BS, Alexandre Bolze, PhD, Matthew E. Levy, PhD, Cassie Hajek, MD, Lisa M. McEwen, PhD, Douglas Stoller, MD, Christopher N. Chapman, MD, C. Anwar A. Chahal, MD, PhD, Daniel P. Judge, MD, Douglas A. Olson, MD, Joseph J. Grzymski, PhD, Nicole L. Washington, PhD, William Lee, PhD, Elizabeth T. Cirulli, PhD, Shishi Luo, PhD, Kelly Schiabor Barrett, PhD
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-10-01
coleção:JACC: Basic to Translational Science
Assuntos:
cardiovascular disease
clinical genetics
genomics
lipoprotein(a)
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452302X2500186X
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