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Lack of Epileptogenic Effects of the Creatine Precursor Guanidinoacetic Acid on Neuronal Cultures In Vitro

The creatine precursor Guanidinoacetic Acid (GAA) accumulates in the genetic deficiency of the GuanidinoAcetate Methyl Transferase (GAMT) enzyme and it is believed to cause the seizures that often occur in this condition. However, evidence that it is indeed epileptogenic is scarce and we previously...

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Principais autores: Fabio Poggio, Martina Brofiga, Mariateresa Tedesco, Paolo Massobrio, Enrico Adriano, Maurizio Balestrino
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-12-01
Series:Biomolecules
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Acceso en liña:https://www.mdpi.com/2218-273X/13/1/74
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