Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation. Recent studies identified the TET hydroxylases as key enzymes responsible for active DNA demethylation, catalyzing the oxi...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2013-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | https://doi.org/10.1371/journal.pone.0082881 |
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