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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterolResearch in context

Summary: Background: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis. Methods: We conducted...

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Asıl Yazarlar: Franz Förster, Katrin Horn, Janne Pott, Graciela E. Delgado, Marcus E. Kleber, Winfried März, Angela Patricia Moissl-Blanke, Günther Silbernagel, Melanie Waldenberger, Harald Grallert, Annette Peters, Christian Gieger, Ronny Baber, Holger Kirsten, Markus Loeffler, Berend Isermann, Joachim Thiery, Peter Kovacs, Anke Tönjes, Michael Stumvoll, Helena Gylling, Mika Kähönen, Terho Lehtimäki, Pashupati Prasad Mishra, Olli Raitakari, Uta Ceglarek, Markus Scholz
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2026-02-01
Seri Bilgileri:EBioMedicine
Konular:
GWAS
Cholesterol biosynthesis
Lanosterol
Desmosterol
Coronary artery disease
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2352396426000253
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