SPACA6-hosted miR-99b~125a~let-7e cluster shapes melanoma resistance by modulating mTOR-mediated immunosuppression

Genomic, non-genomic, and immune alterations contribute to melanoma resistance to BRAF and MEK inhibitors. Here, we investigated the role of the SPACA6-hosted miR-99b~125a~let-7e cluster in modulating inflammatory processes and therapy resistance. We found that miR-99b, miR-125a, and let-7e were upr...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Viviana Vallacchi, Gianpiero Lupoli, Eriomina Shahaj, Mariachiara Aloisi, Stefano Bergamini, Simona Frigerio, Loris De Cecco, Barbara Vergani, Katia Todoerti, Cristina Banfi, Biagio Eugenio Leone, Lorenza Di Guardo, Gianfrancesco Gallino, Mara Cossa, Barbara Valeri, Licia Rivoltini, Veronica Huber, Monica Rodolfo, Elisabetta Vergani
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2026-01-01
Σειρά:	Frontiers in Immunology
Θέματα:	melanoma resistance SPACA6 miR-99b~125a~let-7e cluster PDE 3D models
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1719461/full
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