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Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model

Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutation in the dystrophin gene. Currently there is no cure for DMD. We introduced a novel human Dystrophin Expressing Chimeric (DEC) cell therapy of myoblast origin and confirmed the safety and efficacy of DEC in the <i>mdx</i> mouse m...

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Principais autores: Maria Siemionow, Katarzyna Budzynska, Kristina Zalants, Paulina Langa, Sonia Brodowska, Krzysztof Siemionow, Ahlke Heydemann
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-03-01
Serier:Biomedicines
Fag:
Duchenne Muscular Dystrophy (DMD)
Dystrophin Expressing Chimeric (DEC) cells
DEC therapy
systemic-intraosseous administration
cardiac and skeletal muscle morphology
minimal Feret’s fiber diameter
Online adgang:https://www.mdpi.com/2227-9059/12/3/586
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