Allosteric Conformational Locking of Sestrin2 by Leucine: An Integrated Computational Analysis of Branched-Chain Amino Acid Recognition and Specificity

Sestrin2 (SESN2) is a highly conserved stress-inducible protein that serves as a central hub for integrating cellular responses to nutrient availability, oxidative stress, and endoplasmic reticulum (ER) stress. A key function of SESN2 is its role as a direct sensor for the branched-chain amino acid...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Muhammad Ammar Zahid, Abbas Khan, Mona A. Sawali, Osama Aboubakr Mohamed, Ahmed Mohammad Gharaibeh, Abdelali Agouni
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	MDPI AG 2025-12-01
Σειρά:	Molecules
Θέματα:	Sestrin2 (SESN2) leucine sensing mTORC1 regulation molecular dynamics simulations allosteric stabilization
Διαθέσιμο Online:	https://www.mdpi.com/1420-3049/30/24/4791
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