Adeno-Associated Virus Serotype 9–Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts With Left Ventricular Dysfunction Secondary to a Myocardial Infarction

Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001) improved left ventricular ejection fraction, fraction...

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Detalhes bibliográficos

Principais autores:	Tijana Knezevic, PhD, Valerie D. Myers, MS, Feifei Su, MD, PhD, JuFang Wang, MD, Jianliang Song, MD, PhD, Xue-Qian Zhang, MD, Erhe Gao, MD, PhD, Guofeng Gao, MD, PhD, Muniswamy Madesh, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Kristen N. Weiner, BS, Joseph Rabinowitz, PhD, Frederick V. Ramsey, PhD, Douglas G. Tilley, PhD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-12-01
coleção:	JACC: Basic to Translational Science
Assuntos:	BAG3 gene therapy heart failure left ventricular function myocardial infarction
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452302X16301280
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