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Up-regulation of CB1 cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat

The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate Gi/o proteins in the medial prefrontal cortex (mPCx) of the obese Zucker rats. The...

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Autori principali: Leyre Echeazarra, Sergio Barrondo, Gontzal García del Caño, Itziar Bonilla-Del Río, Jon Egaña-Huguet, Nagore Puente, Xabier Aretxabala, Mario Montaña, Maider López de Jesús, Imanol González-Burguera, Miquel Saumell-Esnaola, María Aránzazu Goicolea, Pedro Grandes, Joan Sallés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-10-01
Serie:Frontiers in Neuroanatomy
Soggetti:
obese Zucker rat
CB1 receptor
Gi/o proteins
2-AG levels
medial prefrontal cortex
glutamatergic terminals
Accesso online:https://www.frontiersin.org/articles/10.3389/fnana.2022.1004702/full
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