Energy Starvation Induces a Cell Cycle Arrest in Escherichia coli by Triggering Degradation of the DnaA Initiator Protein

During steady-state Escherichia coli growth, the amount and activity of the initiator protein, DnaA, controls chromosome replication tightly so that initiation only takes place once per origin in each cell cycle, regardless of growth conditions. However, little is known about the mechanisms involved...

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Detalhes bibliográficos

Principais autores:	Godefroid Charbon, Belén Mendoza-Chamizo, Christopher Campion, Xiaobo Li, Peter Ruhdal Jensen, Jakob Frimodt-Møller, Anders Løbner-Olesen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	Escherichia coli chromosome replication initiation DnaA protein degradation energy starvation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.629953/full
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