Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase and Dihydrofolate Reductase

<i>Trypanosoma</i> and <i>Leishmania</i> parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis. Recently, meaningful progresses in the treatment of HAT, due to...

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Principais autores:	Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-06-01
Series:	Pharmaceuticals
Assuntos:	pyrimethamine cycloguanil derivatives <i>Trypanosoma brucei</i> pteridine reductase dihydrofolate reductase
Acceso en liña:	https://www.mdpi.com/1424-8247/14/7/636
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