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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Abstract Background Biological-derived hydroxyapatite is widely used as a bone substitute for addressing bone defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory properties hold crucial promise in maintaining bone homeostasis, and precise m...

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Hlavní autoři: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-05-01
Edice:Journal of Translational Medicine
Témata:
Metabolic shift
Osteo-immunomodulation
Bone regeneration
Fluoride
Macrophages
On-line přístup:https://doi.org/10.1186/s12967-024-05261-0
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