Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes

In recent years it has been well established that two major constituent parts of the ubiquitin proteasome system (UPS)—the proteasome holoenzymes and a number of ubiquitin ligases—play a crucial role, not only in virus replication but also in the regulation of the immunogenicity of human immunodefic...

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Autors principals:	Christian Setz, Melanie Friedrich, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Maximilian Traxdorf, Ulrich Schubert
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2017-08-01
Col·lecció:	Viruses
Matèries:	HIV-1 DUB-inhibitors UPS DUBs ubiquitination MHC-I proteasome inhibitors
Accés en línia:	https://www.mdpi.com/1999-4915/9/8/222
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