Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway

Although the cellular role of uncoupling protein 2 (UCP2) in tumorigenesis has been reported in various solid tumor models, its role in leukemogenesis remains elusive. Herein, we demonstrated that UCP2 was highly expressed in AML and significantly associated with poor prognosis and chemoresistance,...

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Detalhes bibliográficos

Principais autores:	Agida Okohi Innocent, Yajie Shen, Yixuan Gao, Ruixin Sun, Kasimujiang aximujiang, Zizhen Xu, Jinke Cheng, Jiao Ma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2026-07-01
coleção:	Genes and Diseases
Assuntos:	AML branched-chain amino acids Leukemogenesis Oxidative stress PI3K/AKT/mTORsignaling UCP2
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352304225002831
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