The Jak2 Inhibitor, G6, Alleviates Jak2-V617F–Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow

We recently developed a Janus kinase 2 (Jak2) small-molecule inhibitor called G6 and found that it inhibits Jak2-V617F– mediated pathologic cell growth in vitro, ex vivo, and in vivo. However, its ability to inhibit Jak2-V617F–mediated myeloproliferative neoplasia, with particular emphasis in the bo...

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Hlavní autoři:	Annet Kirabo, Sung O. Park, Anurima Majumder, Meghanath Gali, Mary K. Reinhard, Heather L. Wamsley, Zhizhuang Joe Zhao, Christopher R. Cogle, Kirpal S. Bisht, György M. Keserű, Peter P. Sayeski
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2011-11-01
Edice:	Neoplasia: An International Journal for Oncology Research
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1476558611800928
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