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Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines

Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6-diaminouracil derivatives and various carboxylic acids u...

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Bibliografische Detailangaben
Hauptverfasser: Daniel Marx, Lukas M. Wingen, Gregor Schnakenburg, Christa E. Müller, Matthias S. Scholz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-02-01
Schriftenreihe:Frontiers in Chemistry
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Online-Zugang:https://www.frontiersin.org/article/10.3389/fchem.2019.00056/full
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