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Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease

Abstract Background Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for association but do not meet the strict threshold f...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jarrett D. Morrow, Michael H. Cho, John Platig, Xiaobo Zhou, Dawn L. DeMeo, Weiliang Qiu, Bartholome Celli, Nathaniel Marchetti, Gerard J. Criner, Raphael Bueno, George R. Washko, Kimberly Glass, John Quackenbush, Edwin K. Silverman, Craig P. Hersh
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-01-01
Schriftenreihe:Human Genomics
Schlagworte:
eQTL
Expression QTL
Integrative genomics
Network medicine
Ensemble methods
Bayesian methods
Online-Zugang:http://link.springer.com/article/10.1186/s40246-018-0132-z
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