Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a premutation CGG repeat expansion (55–200 repeats) within the 5′ UTR of the fragile X gene (FMR1). FXTAS is characterized by intension tremor, cerebellar ataxia, progressive neurodegeneration, parkinsonism...

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Detalhes bibliográficos

Principais autores:	Ha Eun Kong, Juan Zhao, Shunliang Xu, Peng Jin, Yan Jin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-05-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	FXTAS pathogenesis CGG repeat RNA toxicity RAN translation FXTAS therapeutics
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00128/full
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