Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

Microtubule assembly and disassembly is the target of many anticancer therapies, with β-tubulin the most-frequent target. Here, the authors used biochemical and biophysical techniques to demonstrate pironetin binds to α-tubulin and thereby inhibits microtubule polymerization providing a basis for th...

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Autors principals:	Jianhong Yang, Yuxi Wang, Taijing Wang, Jian Jiang, Catherine H. Botting, Huanting Liu, Qiang Chen, Jinliang Yang, James H. Naismith, Xiaofeng Zhu, Lijuan Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2016-06-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/ncomms12103
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