Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre‐Synapse and Promote Synaptic Pruning

ABSTRACT C1q is released by microglia, localizes on weak synapses and acts as a tag for microglial synaptic pruning. However, how C1q tags synapses during the pruning period remains to be fully elucidated. Here, we report that C1q is delivered via extracellular vesicles by microglia to pre‐synaptic...

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Detalles Bibliográficos

Principais autores:	Giulia D'Arrigo, Giulia Cutugno, Maria Teresa Golia, Francesca Sironi, Marta Lombardi, Sara Francesca Colombo, Roberto Frigerio, Marina Cretich, Paola Gagni, Elisabetta Battocchio, Cristiana Barone, Emanuele Azzoni, Sonia Bellini, Claudia Saraceno, Roberta Ghidoni, Caterina Bendotti, Rosa Chiara Paolicelli, Martina Gabrielli, Claudia Verderio
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2025-12-01
Series:	Journal of Extracellular Vesicles
Assuntos:	C1q C9orf72 knock out extracellular vesicles microglia synaptic pruning
Acceso en liña:	https://doi.org/10.1002/jev2.70173
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