Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

Background: NLRP3 inflammasome activation in response to several signals, including mitochondrial DNA (mDNA), regulates inflammatory responses by caspase-1 activation and interleukin-1β (IL-1β) release. Circulating mDNA is linked to micro and macrovascular complications in diabetes. However, a role...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Camila A. Pereira, Daniela Carlos, Nathanne S. Ferreira, Josiane F. Silva, Camila Z. Zanotto, Dario S. Zamboni, Valéria D. Garcia, Dora Fix Ventura, João S. Silva, Rita C. Tostes
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-01-01
Schriftenreihe:	Frontiers in Physiology
Schlagworte:	type 1 diabetes endothelial dysfunction NLRP3 inflammasome mitochondrial DNA inflammation reactive oxygen species
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fphys.2019.01557/full
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