Pharmacological inhibition of frizzled 4 delays cell cycle progression and limits oral squamous cell carcinoma growth

Oral squamous cell carcinoma is an aggressive malignancy driven by aberrant signaling pathways, with Wnt signaling acting as a central regulator of proliferation, tumor-microenvironment interactions, and oncogenic growth. Here, we focus on Frizzled-4, a Wnt receptor with context-dependent functions...

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Principais autores:	Riccardo Destefani, Ilaria J. Valookkaran, Sabrina Bensland, Christian T. Meisel, Cristina Porcheri
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-02-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	FZD4 FzM1 oral squamous cell carcinoma retinoic acid Wnt pathway
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1756565/full
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