TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

<p>Abstract</p> <p>Background</p> <p>Trans-activation response element (TAR) DNA binding protein of 43kDa (TDP-43) is causally related to the neurodegenerative diseases frontotemporal dementia and amyotrophic lateral sclerosis being the hallmark protein in the disease-characteristic neuropathologica...

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Autori principali:	Weber Stephanie S, Schurr Christine, Fiesel Fabienne C, Kahle Philipp J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2011-08-01
Serie:	Molecular Neurodegeneration
Soggetti:	TDP-43 RNAi HDAC6 neurite outgrowth SH-SY5Y neuroblastoma frontotemporal dementia amyotrophic lateral sclerosis
Accesso online:	http://www.molecularneurodegeneration.com/content/6/1/64
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