Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into Virions

Interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral factors that restrict the entry of many enveloped viruses, including HIV-1, by modifying host membrane properties and trapping fusion at the hemifusion stage. Beyond blocking entry in target cells, IFITMs also reduce the...

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Detalhes bibliográficos

Principais autores:	Smita Verma, David Prikryl, Mariana Marin, Ruben M. Markosyan, Andrea Cimarelli, Gregory B. Melikyan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-03-01
coleção:	Biomolecules
Assuntos:	IFITM mutants and chimeras HIV negative imprinting target cell protection viral fusion subcellular localization
Acesso em linha:	https://www.mdpi.com/2218-273X/16/3/459
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