A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution

ABSTRACT Understanding the fitness costs associated with plasmid carriage is a key to better understanding the mechanisms of plasmid maintenance in bacteria. In the current work, we performed multiple serial passages (63 days, 627.8 generations) to identify the compensatory mechanisms that Salmonell...

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Autori principali:	Jin-Fei Zhang, Liang-Xing Fang, Man-Xia Chang, Ming Cheng, Hui Zhang, Teng-Fei Long, Qian Li, Xin-lei Lian, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2022-10-01
Serie:	mSystems
Soggetti:	IncHI2 plasmid Salmonella fitness cost adaptive evolution plasmid stability compensatory mutation
Accesso online:	https://journals.asm.org/doi/10.1128/msystems.00248-22
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