Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice

Abstract Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)...

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Ngā kaituhi matua:	Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki  Miwa, Takumi Era, Martin M. Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-11-01
Rangatū:	Molecular Medicine
Ngā marau:	Fibro-adipogenic progenitors (FAPs) Follistatin Obesity Exercise capacity Muscle mass
Urunga tuihono:	https://doi.org/10.1186/s10020-025-01393-1
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