Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models

Abstract Adoptive T cell therapy (ACT) is effective against hematologic cancers, but the mechanisms underlying durable responses in solid tumors remain unclear. We show that adoptively transferred CD8+ T cells that eradicate established murine tumors promote expansion of host CD8+ T cells exhibiting...

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Detalhes bibliográficos

Principais autores:	Diego Figueroa, Juan Pablo Vega, Andrés Hernández-Oliveras, Felipe Ardiles, Sofía Hidalgo, Ximena López, Vicente Saavedra, Catalina Bustamante, Daniela Malavé, Felipe Flores, Felipe Gálvez-Cancino, Hugo Gonzalez, Manuel Varas-Godoy, Maria Rosa Bono, Fabiola Osorio, Vincenzo Borgna, Alvaro Lladser
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-71082-y
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