Topotecan reduces sepsis‐induced acute lung injury and decreases the inflammatory response via the inhibition of the NF‐κB signaling pathway

Abstract This study aims to determine the function of topotecan (TPT) in acute lung injury (ALI) induced by sepsis. The mouse sepsis model was constructed through cecal ligation and puncture (CLP). The ALI score and lung wet/dry (W/D) weight ratio were applied to evaluate the level of lung injury. H...

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Ngā kaituhi matua:	Xiaoxia Wang, Tianxiang Xu, Jiajia Jin, M. M. Ting Gao, Bing Wan, Mei Gong, Lingxiao Bai, Tangfeng Lv, Yong Song
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2022-04-01
Rangatū:	Pulmonary Circulation
Ngā marau:	acute lung injury cecal ligation and puncture inflammation NF‐κB topotecan
Urunga tuihono:	https://doi.org/10.1002/pul2.12070
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!