Differential sensitivity of melanoma cell lines with <it>BRAF</it>^{<it>V600E </it>}mutation to the specific Raf inhibitor PLX4032

<p>Abstract</p> <p>Blocking oncogenic signaling induced by the <it>BRAF</it>^V600Emutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 decreased signaling t...

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Hlavní autoři:	Kehoe Sarah M, Barretina Jordi G, MacConaill Laura E, Sazegar Hooman, Mok Stephen, Hsueh Teli, Guo Deliang, Wang Qi, Nazarian Ramin, Søndergaard Jonas N, Attar Narsis, von Euw Erika, Zuckerman Jonathan E, Chmielowski Bartosz, Comin-Anduix Begoña, Koya Richard C, Mischel Paul S, Lo Roger S, Ribas Antoni
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2010-04-01
Edice:	Journal of Translational Medicine
On-line přístup:	http://www.translational-medicine.com/content/8/1/39
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