Prediction of serum HIV-1 neutralization titers of VRC01 in HIV-uninfected Antibody Mediated Prevention (AMP) trial participants

VRC01 is being evaluated in the AMP efficacy trials, the first assessment of a passively administered broadly neutralizing monoclonal antibody (bnAb) for HIV-1 prevention. A key analysis will assess serum VRC01-mediated neutralization as a potential correlate of protection. To prepare for this analy...

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Bibliografische Detailangaben

Hauptverfasser:	Yunda Huang, Lily Zhang, Amanda Eaton, Nonhlanhla N. Mkhize, Lindsay N. Carpp, Erika Rudnicki, Allan DeCamp, Michal Juraska, April Randhawa, Adrian McDermott, Julie Ledgerwood, Philip Andrew, Shelly Karuna, Srilatha Edupuganti, Nyaradzo Mgodi, Myron Cohen, Lawrence Corey, John Mascola, Peter B. Gilbert, Lynn Morris, David C. Montefiori
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2022-01-01
Schriftenreihe:	Human Vaccines & Immunotherapeutics
Schlagworte:	population pharmacokinetic modeling pharmacokinetics/pharmacodynamics joint modeling correlates analysis monoclonal antibodies hiv-1 prevention broadly neutralizing antibody breakthrough viruses
Online-Zugang:	http://dx.doi.org/10.1080/21645515.2021.1908030
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