Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Abstract Background Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet little is known about the single-cell transcriptomi...

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Principais autores:	Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnendu Roy
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-11-01
Series:	Stem Cell Research & Therapy
Assuntos:	MSC Cell therapy Bone marrow derived MSC (BM-MSC) Cord tissue derived MSC (CT-MSC) scRNA-seq
Acceso en liña:	https://doi.org/10.1186/s13287-021-02627-9
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