Enhanced immunogenicity in mouse by recombinant BCG prime and protein boost based on latency antigen Rv1733c and/or reactivation antigen RpfE

Abstract Background Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), but it fails to prevent the establishment and reactivation of latent TB. Overexpression of latency and reactivation antigens by BCG may enhance its efficacy against latent i...

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Principais autores:	Mitra Ashayeripanah, Bahram Kazemi, Narcis Saubi, Joan Joseph-Munne, Fereshteh Eftekhar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-10-01
coleção:	BMC Infectious Diseases
Assuntos:	Recombinant BCG Mycobacterial recombinant protein Latency antigen Rv1733c Resuscitation promoting factor RpfE Prime-boost Multi-stage tuberculosis vaccine
Acesso em linha:	https://doi.org/10.1186/s12879-025-11534-w
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