Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs
Human protein kinase CK2 is a constitutively active serine/threonine kinase implicated in numerous cancers. Although ATP-competitive inhibitors such as CX-4945 show therapeutic potential, they are limited by off-target effects and incomplete or transient CK2 suppression. PROTACs offer an alternative...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Beilstein-Institut
2026-04-01
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| Edice: | Beilstein Journal of Organic Chemistry |
| Témata: | |
| On-line přístup: | https://doi.org/10.3762/bjoc.22.47 |
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