Structural and functional impact of the p.R163C mutation in the conserved palindromic motif within the C-terminal domain of human αB-crystallin.

Human αB-crystallin is a small heat shock protein that functions as a chaperone and anti-apoptotic protein to maintain cellular protein integrity. A specific mutation (p.R163C) in the C-terminal domain has been linked to dilated cardiomyopathy (DCM). However, the impact of this mutation on the prote...

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Asıl Yazarlar:	Aref Baharvand, Zamara Mariam, Mohammad Bagher Shahsavani, Leila Rezaei Somee, Issa Zarei, Massoud Amanlou, Giuseppe Deganutti, Ali Akbar Saboury, Ali Akbar Moosavi-Movahedi, Reza Yousefi
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Public Library of Science (PLoS) 2025-01-01
Seri Bilgileri:	PLoS ONE
Online Erişim:	https://doi.org/10.1371/journal.pone.0326025
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