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Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14

Summary: Glioblastoma (GBM), the most aggressive primary brain tumor, is marked by high invasiveness that enables resistance to current therapies. Single-cell RNA sequencing analysis reveals that elevated expression of glial intermediate filament (IF) genes correlates with pro-invasive markers in GB...

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Principais autores: Emma J. van Bodegraven, Elvira Infante, Florent Peglion, David Pereira, Yekta Kesenci, Vanessa Roca, Isabelle Perfettini, Emmanuel Terriac, Juliana Geay, Laura Soto, Jacqueline Sluijs, Reinier Rietveld, Shailaja Seetharaman, Batiste Boëda, Jean-Christophe Olivo-Marin, Atef Asnacios, Aleix Boquet-Pujadas, Jean-Baptiste Manneville, Sandrine Etienne-Manneville
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:Cell Reports
Fag:
CP: cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124725013245
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