Insights into spheroid formation: interaction of ovarian cancer cells with macrophage populations in the tumor microenvironment

Abstract Background Treating advanced ovarian cancer (OC) is challenging due to the immunosuppressive tumor microenvironment. This study investigates tumor-immune cell interactions using organotypic spheroid models that simulate the in vivo microenvironment. Methods A dual-model spheroid system was...

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Hauptverfasser:	Simone Pisano, Yajaira Sofia Jimenez, Paul Rees, Jing Xiao, Deyarina Gonzalez, Robert Steven Conlan, Bruna Corradetti
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-10-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Ovarian cancer Immune cells Macrophages Exosomes Spheroids Metastatic processes
Online-Zugang:	https://doi.org/10.1186/s12967-025-07162-2
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