A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive heavily pretreated solid tumors: results from a phase Ia/Ib first-in-human, open-label, single center study

BackgroundIAH0968 is an afucosylated anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody which improved the activity of antibody-dependent cellular cytotoxicity (ADCC) and superior anti-tumor efficacy.MethodsTo determine the maximum tolerated dose (MTD) with dose-limiting toxicity (DL...

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Bibliografski detalji

Glavni autori:	Na Song, Yuee Teng, Jing Shi, Zan Teng, Bo Jin, Jinglei Qu, Lingyun Zhang, Ping Yu, Lei Zhao, Jin Wang, Aodi Li, Linlin Tong, Shujie Jiang, Yang Liu, Liusong Yin, Xiaoling Jiang, Tie Xu, Jian Cui, Xiujuan Qu, Yunpeng Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-11-01
Serija:	Frontiers in Immunology
Teme:	HER2 IAH0968 clinical study safety first-in-human
Online pristup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481326/full
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