Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia.
Regulation of cytosolic calcium (Ca2+) dynamics is fundamental to microglial function. Temporal and spatial Ca2+ fluxes are induced from a complicated signal transduction pathway linked to brain ionic homeostasis. In this paper, we develop a novel biophysical model of Ca2+ and sodium (Na+) dynamics...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2021-11-01
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| Schriftenreihe: | PLoS Computational Biology |
| Online-Zugang: | https://doi.org/10.1371/journal.pcbi.1009520 |
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