Developmental age and clinical illness drive in vivo variability of CYP1A2 ontogeny and caffeine metabolism in preterm neonates

BackgroundCaffeine is the standard therapy for apnea of prematurity and used near-universally in preterm infants. Interindividual variability in clearance, exposure, and clinical responses persists in neonates. CYP1A2 is the primary enzyme responsible for caffeine metabolism in adults, but the enzym...

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Principais autores:	Michelle Chenghuazou Wang, Victoria A. Sealey, Mehzabin Rahman, Malaika Ngugama, Amarine Trolat, Leanne Wybenga-Groot, Michael F. Moran, Jean Dinh, Tamorah Rae Lewis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	CYP1A2 cytochrome P450 drug metabolism neonate - age ontogeny pharmacokinetics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1823969/full
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