The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for super-enhancer function, are a potential therapeut...

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Автори:	Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2023-11-01
Серія:	Breast Cancer Research
Предмети:	Breast cancer Cancer stem cell BET protein degrader ZBC260 Inflammatory cytokines
Онлайн доступ:	https://doi.org/10.1186/s13058-023-01715-3
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