Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells

Abstract Radio-chemotherapy with 5-flu orouracil (5-FU) is the standard of care treatment for patients with colorectal cancer, but it is only effective for a third of them. Despite our understanding of the mechanism of action of 5-FU, drug resistance remains a significant limitation to the clinical...

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Hauptverfasser:	Anaïs Chauvin, Danny Bergeron, Jean Vencic, Dominique Lévesque, Benoit Paquette, Michelle S. Scott, François-Michel Boisvert
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-04-01
Schriftenreihe:	BMC Cancer
Schlagworte:	Colorectal cancer Radiation therapy Chemotherapy 5-fluorouracil DNA damage Drug resistance mechanisms
Online-Zugang:	https://doi.org/10.1186/s12885-022-09417-3
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