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Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma

Abstract Resistance to bortezomib (BTZ) represents a major bottleneck to continue using this proteasome inhibitor in the treatment of mantle cell lymphoma (MCL). In this study, we investigated the mechanisms by which TRIM24 (tripartite motif-containing 24), a ubiquitin ligase enriched in the ubiquit...

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Asıl Yazarlar: Corentin Bouvier, Maria Gonzalez-Santamarta, Núria Profitós-Pelejà, Marc Armengol, Grégoire Quinet, Quentin Alasseur, Laurie Ceccato, Wendy Xolalpa, Raimundo Freire, Julie Guillermet-Guibert, Karine Reybier, Anne-Marie Caminade, Hans C. Beck, Ana Sofia Carvalho, Rune Matthiesen, Jean Christophe Rain, James D. Sutherland, Rosa Barrio, Gaël Roué, Manuel S. Rodriguez
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2025-03-01
Seri Bilgileri:Cell Death Discovery
Online Erişim:https://doi.org/10.1038/s41420-025-02355-6
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