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Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus

Highlights Prenatal BPA exposure altered the transcriptome profiles of genes associated with ASD in the offspring hippocampus through several ASD-related transcription factors, including AR and ESR1, in a sex-dependent manner. In addition to the known BPA targets (i.e., AR and ESR1), other ASD-relat...

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Autori principali: Surangrat Thongkorn, Songphon Kanlayaprasit, Kasidit Kasitipradit, Pattanachat Lertpeerapan, Pawinee Panjabud, Valerie W. Hu, Depicha Jindatip, Tewarit Sarachana
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-02-01
Serie:Biology of Sex Differences
Soggetti:
Sex difference
Endocrine-disrupting chemical
Bisphenol A
Transcription factor
Molecular docking
Androgen receptor
Accesso online:https://doi.org/10.1186/s13293-023-00496-w
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